III-Restricted Avian Monoclonal Antibody: Clonal Deletion with a Novel Clan Characterization of Superantigen-Induced
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A B Cell Superantigen–Induced Persistent “Hole” in the B-1 Repertoire
The bacterial toxin protein A from Staphylococcus aureus (SpA) interacts with B cell antigen receptors encoded by variable region heavy chain (V(H)) clan III genes via a V region framework surface that has been highly conserved during the evolution of the adaptive immune system. We have investigated the consequences of exposure to this prototypic B cell superantigen, and found that treatment of...
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